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| Agent Info | |
| Agent: | AZD0530 |
| Synonyms: | Saracatinib;H8H;AZD-0530;Saracatinib, AZD-0530, AZD0530;N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine;4-(6-Chloro-2,3-methylenedioxyanilino)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-tetrahydropyran-4-yloxyquinazoline |
| Drug Status For Certain Diseases: | phase II(Osteosarcoma;Hematological malignancies;Solid tumours) |
| Classification: | Src-kinase inhibitor |
| Target: | Proto-oncogene tyrosine-protein kinase SRC Abl |
| KEGG Pathway: | Shigellosis Tuberculosis Inflammatory mediator regulation of TRP channels Pathways in cancer Endocytosis Regulation of actin cytoskeleton Oxytocin signaling pathway Ras signaling pathway Adherens junction Gap junction Platelet activation Viral carcinogenesis Focal adhesion VEGF signaling pathway Rap1 signaling pathway Viral myocarditis Thyroid hormone signaling pathway Tight junction Chronic myeloid leukemia Neurotrophin signaling pathway Estrogen signaling pathway GnRH signaling pathway GABAergic synapse Bacterial invasion of epithelial cells Prolactin signaling pathway Epithelial cell signaling in Helicobacter pylori infection Axon guidance ErbB signaling pathway |
| Wiki Pathway: | BDNF signaling pathway RANKL/RANK Signaling Pathway Integrin-mediated Cell Adhesion Senescence and Autophagy in Cancer Notch Signaling Pathway Signaling of Hepatocyte Growth Factor Receptor Arylhydrocarbon receptor (AhR) signaling pathway Leptin signaling pathway Androgen receptor signaling pathway ATM Signaling Pathway Integrated Pancreatic Cancer Pathway EPO Receptor Signaling TSLP Signaling Pathway Oncostatin M Signaling Pathway AGE/RAGE pathway Signaling by Robo receptor ErbB Signaling Pathway TGF beta Signaling Pathway Alpha 6 Beta 4 signaling pathway Signaling Pathways in Glioblastoma Apoptosis-related network due to altered Notch3 in ovarian cancer Factors involved in megakaryocyte development and platelet production Kit receptor signaling pathway Angiogenesis Fcgamma receptor (FCGR) dependent phagocytosis Retinoblastoma (RB) in Cancer Myogenesis IL-3 Signaling Pathway Nanoparticle-mediated activation of receptor signaling Polycystic Kidney Disease Pathway Interleukin-11 Signaling Pathway Aryl Hydrocarbon Receptor Pathway Pregnane X Receptor pathway EGF/EGFR Signaling Pathway Integrated Breast Cancer Pathway FSH signaling pathway Pathogenic Escherichia coli infection Regulation of Microtubule Cytoskeleton |