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| Agent Info | |
| Agent: | GSK2118436 |
| Synonyms: | NA |
| Drug Status For Certain Diseases: | Metastatic melanoma;Solid tumors(phase I/II) |
| Classification: | a highly potent and selective ATP competitive BRAF inhibitor with > 100-fold selectivity for mutant (mut) BRAF over wild type (wt) in cell lines. It displays dose-dependent inhibition of MEK and ERK phosphorylation in mut BRAF cell lines and tumor regression in xenograft models. |
| Target: | B-Raf proto-oncogene serine/threonine-protein kinase |
| KEGG Pathway: | NA |
| Wiki Pathway: | Bladder Cancer Focal Adhesion TSH signaling pathway Senescence and Autophagy in Cancer Serotonin HTR1 Group and FOS Pathway Regulation of Actin Cytoskeleton Corticotropin-releasing hormone B Cell Receptor Signaling Pathway Signaling Pathways in Glioblastoma Integrated Breast Cancer Pathway Signaling by FGFR EGF/EGFR Signaling Pathway Integrin-mediated Cell Adhesion Serotonin Receptor 4/6/7 and NR3C Signaling NGF signalling via TRKA from the plasma membrane MAPK Signaling Pathway Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Polycystic Kidney Disease Pathway Estrogen signaling pathway MAPK Cascade |