View Agent
| Agent Info | |
| Agent: | Vorinostat and erlotinib |
| Synonyms: | NHNPODA;SAHA;SHH;Zolinza;Merck brand of Vorinostat;OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE;SAHA cpd;Suberanilohydroxamic acid;Suberoylanilide hydroxamic acid;Vorinostat MSD;Vorinostat [USAN];M344;MK0683;SKI390;WIN64652;MK-0683;SAHA, Suberoylanilide hydroxamic acid;SW-064652;Zolinza (TN);Vorinostat (JAN/USAN);N1-hydroxy-N8-phenyloctanediamide;Zolinza, MK-0683, SAHA;N'-hydroxy-N-phenyloctanediamide;N-Hydroxy-N'-phenyl octanediamide;N-Hyrdroxy-N'-phenyloctanediamide;N-hydroxy-N'-phenyloctanediamide;N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide |
| Drug Status For Certain Diseases: | NA |
| Classification: | a novel histone deacetylase inhibitor with demonstrated antiproliferative effects due to drug-induced accumulation of acetylated proteins, including the heat shock protein 90 |
| Target: | Histone deacetylase 1 |
| KEGG Pathway: | MicroRNAs in cancer Huntington's disease Alcoholism Pathways in cancer Viral carcinogenesis Thyroid hormone signaling pathway Amphetamine addiction Transcriptional misregulation in cancer Chronic myeloid leukemia Cell cycle Notch signaling pathway |
| Wiki Pathway: | Cell Cycle SIDS Susceptibility Pathways RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signalling by NGF Integrated Breast Cancer Pathway Transcriptional activity of SMAD2/SMAD3 TtheyAK Signaling Pathway Androgen receptor signaling pathway Apoptosis-related network due to altered Notch3 in ovarian cancer TGF beta Signaling Pathway Notch Signaling Pathway Neural Crest Differentiation Notch Signaling Pathway Mitotic G1-G1/Sphases Retinoblastoma (RB) in Cancer IL-6 signaling pathway Factors involved in megakaryocyte development and platelet production |