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| Agent Info | |
| Agent: | afatinib |
| Synonyms: | BIBW2992;Tomtovok;Tovok;BIBW-2992;Tovok (TN);Tovok, BIBW2992;(2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide |
| Drug Status For Certain Diseases: | Metastatic NSCLC with EGFR exon 19 deletion or exon 21 (L858R) mutations (Approved) |
| Classification: | 2nd-generation, orally available, irreversibly binding ErbB family blocker with the ability to block signaling from EGFR (ErbB1), human epidermal growth factor receptor 2 (human epidermal growth factor receptor 2/ErbB2), ErbB4, and all relevant ErbB family dimers |
| Target: | Receptor protein-tyrosine kinase erbB-2 Epidermal growth factor receptor |
| KEGG Pathway: | non-small-cell lung cancer Bladder cancer ErbB signaling pathway Central carbon metabolism in cancer Prostate cancer Calcium signaling pathway Pathways in cancer HIF-1 signaling pathway Pancreatic cancer Adherens junction Focal adhesion MicroRNAs in cancer Endometrial cancer |
| Wiki Pathway: | Hair Follicle Development L1CAM interactions miR-targeted genes in muscle cell - TarBase MAPK Signaling Pathway Aryl Hydrocarbon Receptor Pathway Nanoparticle-mediated activation of receptor signaling Signaling Pathways in Glioblastoma Gastric cancer network 2 miR-targeted genes in lymphocytes - TarBase Signaling by EGFR Signaling by ERBB4 PIP3 activates AKT signaling EGF/EGFR Signaling Pathway Semaphorin interactions Aryl Hydrocarbon Receptor Spinal Cord Injury Integrated Pancreatic Cancer Pathway Gastrin-CREB signalling pathway via PKC and MAPK Hair Follicle Development Extracellular vesicle-mediated signaling in recipient cells ErbB Signaling Pathway Integrated Breast Cancer Pathway TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer Leptin signaling pathway Signaling by ERBB2 Bladder Cancer DNA Damage Response (only ATM dependent) miR-targeted genes in epithelium - TarBase Arylhydrocarbon receptor (AhR) signaling pathway AGE/RAGE pathway Focal Adhesion Regulation of Actin Cytoskeleton |