View Agent
| Agent Info | |
| Agent: | aflibercept |
| Synonyms: | VEGF-Trap, ziv-aflibercept, AVE0005, Zaltrap (TN) |
| Drug Status For Certain Diseases: | Approved(Metastatic colorectal cancer) |
| Classification: | a recombinant fusion protein containing VEGF-binding portions from the extracellular domains of human VEGF receptors 1 and 2, fused to the Fc portion of human immunoglobulin (Ig)G1. |
| Target: | VEGFA vascular endothelial growth factor B PIGF |
| KEGG Pathway: | Ras signaling pathway Rap1 signaling pathway PI3K-Akt signaling pathway Endocytosis VEGF signaling pathway |
| Wiki Pathway: | Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis Nifedipine Activity SIDS Susceptibility Pathways Diurnally Regulated Genes with Circadian Orthologs Integrated Breast Cancer Pathway Aryl Hydrocarbon Receptor Regulation of Hypoxia-inducible Factor (HIF) by Oxygen Bladder Cancer Differentiation Pathway Focal Adhesion Angiogenesis Signaling by VEGF Integrated Pancreatic Cancer Pathway Hypertrophy Model Allograft Rejection Endochondral Ossification Oncostatin M Signaling Pathway Heart Development Post-translational modification |