| Agent Info |
| Agent: | bortezomib |
| Synonyms: | DPBA;PROSCRIPT BORONIC ACID;LPD 341;LDP-341;LPD-341;PS-341;VELCADE (TN);Velcade (TN);Pyz-Phe-boroLeu;Bortezomib (JAN/USAN/INN);Velcade, MG-341, PS-341, Bortezomib;[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid;N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE;N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide |
| Drug Status For Certain Diseases: | Multiple myeloma(approved);NHL,MCL(phase III) |
| Classification: | a specific inhibitor of the 26S proteasome and affects multiple signaling pathways in cancer cells, including the inhibition of the NF-kB pathway |
| Target: | 26S proteasome
|
| KEGG Pathway: | multiple signaling pathways in cancer cells(NF-kB pathway ) |
| Wiki Pathway: | NA |