CMTTdb

An integrated database for cancer molecular targeted thearpies

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Agent Info
Agent:bosutinib
Synonyms:SKI 606;SKI606;Bosutinib (USAN);PF-5208763;SKI-606;Xy]-3-quinolinecarbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile;4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile;4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile;4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo;4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
Drug Status For Certain Diseases:Philadelphia chromosome positive CML(approved);Advanced breast cancer(phase I/II)
Classification:a tyrosine kinase inhibitor that potently inhibits Src and Abl
Target:Proto-oncogene tyrosine-protein kinase SRC
Abl
KEGG Pathway:Axon guidance
Focal adhesion
Tight junction
Ras signaling pathway
Pathways in cancer
Viral myocarditis
Epithelial cell signaling in Helicobacter pylori infection
ErbB signaling pathway
Endocytosis
Inflammatory mediator regulation of TRP channels
Neurotrophin signaling pathway
Rap1 signaling pathway
Bacterial invasion of epithelial cells
Viral carcinogenesis
VEGF signaling pathway
GABAergic synapse
Prolactin signaling pathway
Chronic myeloid leukemia
Adherens junction
Regulation of actin cytoskeleton
Estrogen signaling pathway
Thyroid hormone signaling pathway
Shigellosis
Tuberculosis
GnRH signaling pathway
Gap junction
Platelet activation
Oxytocin signaling pathway
Wiki Pathway:Integrin-mediated Cell Adhesion
Androgen receptor signaling pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
FSH signaling pathway
Angiogenesis
Retinoblastoma (RB) in Cancer
Integrated Breast Cancer Pathway
Signaling by Robo receptor
Factors involved in megakaryocyte development and platelet production
Signaling of Hepatocyte Growth Factor Receptor
Arylhydrocarbon receptor (AhR) signaling pathway
Pathogenic Escherichia coli infection
Oncostatin M Signaling Pathway
Signaling Pathways in Glioblastoma
ErbB Signaling Pathway
TGF beta Signaling Pathway
Kit receptor signaling pathway
Nanoparticle-mediated activation of receptor signaling
Alpha 6 Beta 4 signaling pathway
Leptin signaling pathway
EGF/EGFR Signaling Pathway
Myogenesis
TSLP Signaling Pathway
BDNF signaling pathway
Notch Signaling Pathway
Senescence and Autophagy in Cancer
ATM Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Polycystic Kidney Disease Pathway
Pregnane X Receptor pathway
Fcgamma receptor (FCGR) dependent phagocytosis
RANKL/RANK Signaling Pathway
IL-3 Signaling Pathway
Aryl Hydrocarbon Receptor Pathway
EPO Receptor Signaling
Integrated Pancreatic Cancer Pathway
Regulation of Microtubule Cytoskeleton