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| Agent Info | |
| Agent: | dasatinib |
| Synonyms: | Dasatinibum;Sprycel;Spyrcel;Dasatinib [USAN];Dasatinib anhydrous;BMS 354825;BMS354825;BMS-354825;Dasatinib (USAN);Dasatinib, BMS 354825;SPRYCEL (TN);Sprycel (TN);BMS-354825, Sprycel, BMS354825, Dasatinib;N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate;N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide;N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE;(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide;2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide |
| Drug Status For Certain Diseases: | Philadelphia chromosome positive CML, Philadelphia chromosome positive ALL(approved);Solid tumours;Multiple myeloma(phase II) |
| Classification: | an oral tyrosine kinase inhibitor with potent activity against SRC and SRC family kinases, BCR-ABL, platelet-derived growth factor receptor, and c-KIT. |
| Target: | Proto-oncogene tyrosine-protein kinase SRC Abl Proto-oncogene tyrosine-protein kinase LCK Proto-oncogene tyrosine-protein kinase Fyn |
| KEGG Pathway: | Pathways in cancer ErbB signaling pathway Natural killer cell mediated cytotoxicity Osteoclast differentiation Oxytocin signaling pathway Prolactin signaling pathway Regulation of actin cytoskeleton Focal adhesion Endocytosis HTLV-I infection T cell receptor signaling pathway Tuberculosis Thyroid hormone signaling pathway GABAergic synapse Adherens junction NF-kappa B signaling pathway Cholinergic synapse Rap1 signaling pathway Tight junction Estrogen signaling pathway Bacterial invasion of epithelial cells Sphingolipid signaling pathway Measles Shigellosis Prion diseases Pathogenic Escherichia coli infection Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels Viral carcinogenesis Axon guidance Viral myocarditis VEGF signaling pathway Gap junction Platelet activation GnRH signaling pathway Primary immunodeficiency Ras signaling pathway Chronic myeloid leukemia Epithelial cell signaling in Helicobacter pylori infection |
| Wiki Pathway: | Retinoblastoma (RB) in Cancer Costimulation by the CD28 family IL-3 Signaling Pathway Interferon type I signaling pathways Primary Focal Segmental Glomerulosclerosis FSGS Semaphorin interactions NCAM signaling for neurite out-growth Inflammatory Response Pathway Integrated Pancreatic Cancer Pathway Signaling by Robo receptor Factors involved in megakaryocyte development and platelet production Aryl Hydrocarbon Receptor Pathway Alpha 6 Beta 4 signaling pathway Leptin signaling pathway Signaling by the B Cell Receptor (BCR) PIP3 activates AKT signaling Platelet Adhesion to exposed collagen Nephrin interactions TGF beta Signaling Pathway Interleukin-11 Signaling Pathway TSLP Signaling Pathway Arylhydrocarbon receptor (AhR) signaling pathway FSH signaling pathway Netrin-1 signaling Cell surface interactions at the vascular wall Myogenesis EPO Receptor Signaling EGF/EGFR Signaling Pathway Kit receptor signaling pathway RANKL/RANK Signaling Pathway Androgen receptor signaling pathway Ectoderm Differentiation DAP12 interactions ATM Signaling Pathway Regulation of Microtubule Cytoskeleton Notch Signaling Pathway Signaling of Hepatocyte Growth Factor Receptor Polycystic Kidney Disease Pathway T-Cell Receptor and Co-stimulatory Signaling GPVI-mediated activation cascade Apoptosis-related network due to altered Notch3 in ovarian cancer Fcgamma receptor (FCGR) dependent phagocytosis Integrated Breast Cancer Pathway Pregnane X Receptor pathway Oncostatin M Signaling Pathway AGE/RAGE pathway Integrin-mediated Cell Adhesion Signaling by SCF-KIT Host Interactions of HIV factors TCR signaling ErbB Signaling Pathway Senescence and Autophagy in Cancer Nanoparticle-mediated activation of receptor signaling BDNF signaling pathway Signaling Pathways in Glioblastoma Angiogenesis TCR Signaling Pathway IL-2 Signaling Pathway IL-7 Signaling Pathway Fc epsilon receptor (FCERI) signaling B Cell Receptor Signaling Pathway Pathogenic Escherichia coli infection |