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| Agent Info | |
| Agent: | erlotinib |
| Synonyms: | Erlotinin;Tarceva;Erlotinib Base;AQ4;OSI 744;R 1415;CP 358,774;CP-358774;Erlotinib(Tarceva);Tarceva (TN);CP-358,774;Erlotinib, OS-774;N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine;N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine;N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine;[6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE;[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine;4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline;4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline |
| Drug Status For Certain Diseases: | Metastatic or locally advanced NSCLC, with EGFR exon 19 deletion or L858R substitution;Metastatic or advanced pancreatic cancer in combination with gemcitabine(Approved) |
| Classification: | 1st-generation EGFR TKI,a receptor tyrosine kinase inhibitor with specificity for the EGFR/HER1 |
| Target: | Epidermal growth factor receptor |
| KEGG Pathway: | NA |
| Wiki Pathway: | miR-targeted genes in epithelium - TarBase Spinal Cord Injury Focal Adhesion Arylhydrocarbon receptor (AhR) signaling pathway Signaling by ERBB4 Extracellular vesicle-mediated signaling in recipient cells Hair Follicle Development Aryl Hydrocarbon Receptor Pathway Regulation of Actin Cytoskeleton PIP3 activates AKT signaling Signaling Pathways in Glioblastoma miR-targeted genes in lymphocytes - TarBase EGF/EGFR Signaling Pathway L1CAM interactions Signaling by EGFR Integrated Breast Cancer Pathway Integrated Pancreatic Cancer Pathway Aryl Hydrocarbon Receptor Nanoparticle-mediated activation of receptor signaling Bladder Cancer miR-targeted genes in muscle cell - TarBase AGE/RAGE pathway Gastric cancer network 2 Gastrin-CREB signalling pathway via PKC and MAPK TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer MAPK Signaling Pathway Hair Follicle Development Signaling by ERBB2 ErbB Signaling Pathway |