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| Agent Info | |
| Agent: | everolimus |
| Synonyms: | Afinitor;Certican;Zortress;Everolimus [USAN];RAD 001;RAD001;Afinitor (TN);CERTICAN(R);Certican (TN);RAD-001;RAD-001C;SDZ-RAD;NVP-RAD-001;Everolimus (JAN/USAN/INN);RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus;(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy;40-O-(2-hydroxyethyl)-rapamycin;42-O-(2-Hydroxyethyl)rapamycin |
| Drug Status For Certain Diseases: | Advanced kidney cancer(phase III);Renal cell carcinoma(approved) |
| Classification: | an oral small-molecule serine-threonine kinase inhibitor of mTOR |
| Target: | Serine/threonine-protein kinase mTOR |
| KEGG Pathway: | Insulin signaling pathway HIF-1 signaling pathway AMPK signaling pathway Acute myeloid leukemia MicroRNAs in cancer Type II diabetes mellitus PI3K-Akt signaling pathway Pathways in cancer Prostate cancer Choline metabolism in cancer Central carbon metabolism in cancer Adipocytokine signaling pathway Thyroid hormone signaling pathway Glioma mTOR signaling pathway |
| Wiki Pathway: | Insulin Signaling Polycystic Kidney Disease Pathway BDNF signaling pathway SREBF and miR33 in cholesterol and lipid homeostasis SREBP signalling ErbB Signaling Pathway FSH signaling pathway RANKL/RANK Signaling Pathway Type II diabetes mellitus Wnt Signaling Pathway Netpath Alpha 6 Beta 4 signaling pathway Costimulation by the CD28 family MicroRNAs in cardiomyocyte hypertrophy EGF/EGFR Signaling Pathway Extracellular vesicle-mediated signaling in recipient cells Oncostatin M Signaling Pathway Leptin signaling pathway Interferon type I signaling pathways PIP3 activates AKT signaling Prostate Cancer Senescence and Autophagy in Cancer Cardiac Hypertrophic Response Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) TSLP Signaling Pathway Signaling by Insulin receptor AMPK Signaling TSH signaling pathway Integrated Breast Cancer Pathway TOR Signaling |