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| Agent Info | |
| Agent: | gefitinib |
| Synonyms: | Gefitini;IRE;Iressa;Irressat;Gefitinib [USAN];ZD 1839;ZD1839;Iressa (TN);Iressa(TM);ZD-1839;CU-00000000396-1;Gefitinib, Iressa, ZD1839;Gefitinib (JAN/USAN/INN);ZD-1839, Iressa, Gefitinib;N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine;N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline;6-(3-morpholinopropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine |
| Drug Status For Certain Diseases: | Metastatic NSCLC with EGFR exon 19 deletions or exon 21 (L858R) substitution mutations(approved); |
| Classification: | 1st-generation EGFR TKI,reversible |
| Target: | Epidermal growth factor receptor |
| KEGG Pathway: | NA |
| Wiki Pathway: | MAPK Signaling Pathway Signaling by ERBB2 Arylhydrocarbon receptor (AhR) signaling pathway miR-targeted genes in muscle cell - TarBase Signaling by ERBB4 ErbB Signaling Pathway EGF/EGFR Signaling Pathway PIP3 activates AKT signaling Nanoparticle-mediated activation of receptor signaling L1CAM interactions Regulation of Actin Cytoskeleton Integrated Pancreatic Cancer Pathway miR-targeted genes in lymphocytes - TarBase miR-targeted genes in epithelium - TarBase Signaling by EGFR Signaling Pathways in Glioblastoma Gastric cancer network 2 Gastrin-CREB signalling pathway via PKC and MAPK Bladder Cancer Aryl Hydrocarbon Receptor Pathway AGE/RAGE pathway Aryl Hydrocarbon Receptor Hair Follicle Development Hair Follicle Development Focal Adhesion Integrated Breast Cancer Pathway Spinal Cord Injury Extracellular vesicle-mediated signaling in recipient cells TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer |