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| Agent Info | |
| Agent: | imatinib mesylate |
| Synonyms: | Glamox;STI;Imatinib Methansulfonate;Imatinib free base;CGP 57148B;Cgp 57148;STI 571;STI571;Glamox (TN);Gleevec (TN);Glivec (TN);Imatinib (INN);Imatinib [INN:BAN];Sti-571;Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-(9CI);Alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide;N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide;112GI019;4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE;4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide;4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide methanesulfonate;4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide;4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide |
| Drug Status For Certain Diseases: | Philadelphia chromosome positive ALL and CLL. MDS, chronic myeloproliferative disorder. Chronic eosinophilic leukaemia. Hypereosinophilic syndrome. Dermatofibrosis protuberans;GIST (approved) |
| Classification: | an orally available ATP-competitive inhibitor of several tyrosine kinases including KIT |
| Target: | Abl Platelet-derived growth factor receptor Mast/stem cell growth factor receptor |
| KEGG Pathway: | Hematopoietic cell lineage Melanogenesis Central carbon metabolism in cancer PI3K-Akt signaling pathway Ras signaling pathway Neurotrophin signaling pathway Pathways in cancer Chronic myeloid leukemia Viral myocarditis Cytokine-cytokine receptor interaction Acute myeloid leukemia Endocytosis Rap1 signaling pathway Axon guidance |
| Wiki Pathway: | miR-targeted genes in muscle cell - TarBase miR-targeted genes in epithelium - TarBase Cardiac Progenitor Differentiation ATM Signaling Pathway Apoptosis-related network due to altered Notch3 in ovarian cancer Pathogenic Escherichia coli infection Integrated Breast Cancer Pathway Differentiation Pathway Myogenesis Signaling by SCF-KIT PIP3 activates AKT signaling Factors involved in megakaryocyte development and platelet production Signaling by Robo receptor Kit receptor signaling pathway miR-targeted genes in lymphocytes - TarBase Regulation of Microtubule Cytoskeleton Retinoblastoma (RB) in Cancer Integrated Pancreatic Cancer Pathway Fcgamma receptor (FCGR) dependent phagocytosis |