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| Agent Info | |
| Agent: | lapatinib |
| Synonyms: | FMM;Tycerb;Lapatinib Ditosylate;Lapatinib [INN];Lapatinib tosilate hydrate;GSK 572016;GSK572016;GW 572016;GW 572016X;GW572016;Lapatinib (INN);Tykerb (TN);Lapatinib, Tykerb, GW572016;N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE;N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine;N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine;4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline |
| Drug Status For Certain Diseases: | HER-2-overexpressing breast cancer(approved) |
| Classification: | an inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2/NEU |
| Target: | Epidermal growth factor receptor Receptor protein-tyrosine kinase erbB-2 |
| KEGG Pathway: | Calcium signaling pathway Focal adhesion Pathways in cancer Pancreatic cancer Central carbon metabolism in cancer Bladder cancer Prostate cancer MicroRNAs in cancer Endometrial cancer Adherens junction HIF-1 signaling pathway ErbB signaling pathway non-small-cell lung cancer |
| Wiki Pathway: | miR-targeted genes in muscle cell - TarBase Hair Follicle Development Arylhydrocarbon receptor (AhR) signaling pathway Bladder Cancer Aryl Hydrocarbon Receptor Spinal Cord Injury Integrated Breast Cancer Pathway Signaling by EGFR Aryl Hydrocarbon Receptor Pathway TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer Nanoparticle-mediated activation of receptor signaling miR-targeted genes in lymphocytes - TarBase Focal Adhesion Signaling by ERBB2 Regulation of Actin Cytoskeleton PIP3 activates AKT signaling Semaphorin interactions Hair Follicle Development AGE/RAGE pathway Leptin signaling pathway Signaling by ERBB4 L1CAM interactions ErbB Signaling Pathway Extracellular vesicle-mediated signaling in recipient cells Signaling Pathways in Glioblastoma miR-targeted genes in epithelium - TarBase DNA Damage Response (only ATM dependent) MAPK Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Gastric cancer network 2 EGF/EGFR Signaling Pathway Integrated Pancreatic Cancer Pathway |