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| Agent Info | |
| Agent: | motesanib |
| Synonyms: | AMG 706;AMG706;AMG-706;N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-((4-pyridinylmethyl)amino)-3-pyridinecarboxamide;N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide |
| Drug Status For Certain Diseases: | non-small-cell lung cancer(Discontinued inphase 3) |
| Classification: | a small-molecule inhibitor of vascular endothelial growth factor receptors |
| Target: | Mast/stem cell growth factor receptor Platelet-derived growth factor receptor Vascular endothelial growth factor receptor 2 |
| KEGG Pathway: | PI3K-Akt signaling pathway Ras signaling pathway Central carbon metabolism in cancer Acute myeloid leukemia Melanogenesis VEGF signaling pathway Endocytosis Pathways in cancer Cytokine-cytokine receptor interaction Rap1 signaling pathway Hematopoietic cell lineage |
| Wiki Pathway: | miR-targeted genes in epithelium - TarBase Cardiac Progenitor Differentiation miR-targeted genes in muscle cell - TarBase Signaling by VEGF miR-targeted genes in lymphocytes - TarBase Kit receptor signaling pathway PIP3 activates AKT signaling Angiogenesis Differentiation Pathway Signaling by SCF-KIT Nifedipine Activity Focal Adhesion |