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| Agent Info | |
| Agent: | navitoclax |
| Synonyms: | Navitoclax;ABT 263;S1001_Selleck;ABT263, Navitoclax;4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({4-({(1R)-3-morpholin-4-yl-1-[(phenylsulfanyl)methyl]propyl}amino)-3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)benzamide |
| Drug Status For Certain Diseases: | Advanced SCLC;Relapsed or refractory CLL;Lymphoid malignancies(phase II) |
| Classification: | a potent and highly selective inhibitor of antiapoptotic members of the Bcl-2 family, with nanomolar affinity for Bcl-2, Bcl-xL, and Bcl-w. |
| Target: | Bcl-2-like protein 2 Antiapoptotic protein BCL-XL Apoptosis regulator Bcl-2 |
| KEGG Pathway: | Toxoplasmosis Apoptosis Tuberculosis PI3K-Akt signaling pathway Sphingolipid signaling pathway Prostate cancer Epstein-Barr virus infection MicroRNAs in cancer Small cell lung cancer Pancreatic cancer Hepatitis B Chronic myeloid leukemia Amyotrophic lateral sclerosis (ALS) Transcriptional misregulation in cancer Protein processing in endoplasmic reticulum HIF-1 signaling pathway Colorectal cancer Pathways in cancer |
| Wiki Pathway: | Intrinsic Pathway for Apoptosis Kit receptor signaling pathway Nanoparticle triggered autophagic cell death miR-targeted genes in leukocytes - TarBase IL-2 Signaling Pathway Corticotropin-releasing hormone Influenza A virus infection IL-7 Signaling Pathway Leptin signaling pathway DNA Damage Response (only ATM dependent) FAS pathway and Stress induction of HSP regulation Focal Adhesion Prostate Cancer miR-targeted genes in muscle cell - TarBase IL-5 Signaling Pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Amyotrophic lateral sclerosis (ALS) Apoptosis Modulation and Signaling TP53 Network IL-3 Signaling Pathway Senescence and Autophagy in Cancer Integrated Breast Cancer Pathway Integrated Cancer pathway TNF alpha Signaling Pathway Interleukin-11 Signaling Pathway miR-targeted genes in lymphocytes - TarBase IL-6 signaling pathway Apoptosis Integrated Pancreatic Cancer Pathway |