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| Agent Info | |
| Agent: | neratinib |
| Synonyms: | NA |
| Drug Status For Certain Diseases: | Lymphoma(phase III) |
| Classification: | 2nd-generation,reversible pan-EGFR family tyrosine kinase inhibitor（dual EGFR/human epidermal growth factor receptor 2 TKIs ） |
| Target: | mRNA of human epidermal growth factor receptor 2 Vascular endothelial growth factor receptor 2 Epidermal growth factor receptor |
| KEGG Pathway: | Ras signaling pathway non-small-cell lung cancer Endometrial cancer Pancreatic cancer Adherens junction ErbB signaling pathway VEGF signaling pathway Rap1 signaling pathway Pathways in cancer Central carbon metabolism in cancer PI3K-Akt signaling pathway Prostate cancer MicroRNAs in cancer Endocytosis Bladder cancer |
| Wiki Pathway: | EGF/EGFR Signaling Pathway L1CAM interactions Hair Follicle Development Spinal Cord Injury Gastric cancer network 2 miR-targeted genes in epithelium - TarBase MAPK Signaling Pathway TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ErbB Signaling Pathway Signaling by ERBB2 Signaling by ERBB4 miR-targeted genes in lymphocytes - TarBase DNA Damage Response (only ATM dependent) Integrated Pancreatic Cancer Pathway Leptin signaling pathway Focal Adhesion Aryl Hydrocarbon Receptor Pathway Aryl Hydrocarbon Receptor Signaling by EGFR Nifedipine Activity Regulation of Actin Cytoskeleton PIP3 activates AKT signaling Nanoparticle-mediated activation of receptor signaling Arylhydrocarbon receptor (AhR) signaling pathway Extracellular vesicle-mediated signaling in recipient cells Bladder Cancer miR-targeted genes in muscle cell - TarBase Signaling by VEGF Gastrin-CREB signalling pathway via PKC and MAPK Integrated Breast Cancer Pathway Signaling Pathways in Glioblastoma Semaphorin interactions Cardiac Progenitor Differentiation Hair Follicle Development AGE/RAGE pathway Angiogenesis |