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| Agent Info | |
| Agent: | regorafenib |
| Synonyms: | NA |
| Drug Status For Certain Diseases: | Metastatic colorectal cancer,GIST(approved) |
| Classification: | a novel oral multikinase inhibitor that blocks the activity of several protein kinases, including kinases involved in the regulation of tumour angiogenesis (VEGFR1 [FLT1], VEGFR2 [KDR], VEGFR3 [FLT4], TIE2 [TEK]), oncogenesis (KIT, RET, RAF1, BRAF, and BRAFV600E), and the tumour microenvironment (PDGFR and FGFR). |
| Target: | Proto-oncogene tyrosine-protein kinase receptor ret Mast/stem cell growth factor receptor Vascular endothelial growth factor receptor 2 Vascular endothelial growth factor receptor 3 |
| KEGG Pathway: | Endocytosis PI3K-Akt signaling pathway Rap1 signaling pathway VEGF signaling pathway Melanogenesis Central carbon metabolism in cancer Thyroid cancer Hematopoietic cell lineage Acute myeloid leukemia Pathways in cancer Cytokine-cytokine receptor interaction Ras signaling pathway |
| Wiki Pathway: | PIP3 activates AKT signaling Nifedipine Activity Signaling by SCF-KIT miR-targeted genes in lymphocytes - TarBase SIDS Susceptibility Pathways Kit receptor signaling pathway miR-targeted genes in muscle cell - TarBase Angiogenesis Differentiation Pathway Signaling by VEGF miR-targeted genes in epithelium - TarBase Cardiac Progenitor Differentiation Dopaminergic Neurogenesis Focal Adhesion |