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| Agent Info | |
| Agent: | sirolimus/rapamycin |
| Synonyms: | Perceiva;RAP;RAPA;RPM;Rapammune;Rapamune;Rapamycin;Rapamycin Immunosuppressant Drug;Rapamycin from Streptomyces hygroscopicus;AY 22989;Antibiotic AY 22989;SIIA 9268A;SILA 9268A;Wy 090217;AY-22989;DE-109;LCP-Siro;MS-R001;Rapamune (TN);Rapamycin (TN);Sirolimus (RAPAMUNE);WY-090217;Rapamycin C-7, analog 4;Sirolimus (USAN/INN);Sirolimus [USAN:BAN:INN];Sirolimus, Rapamune,Rapamycin;Heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy;(-)-Rapamycin;23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine;23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29;3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone |
| Drug Status For Certain Diseases: | Multiple myeloma;Coronary artery restenosis(approved) |
| Classification: | mammalian target of rapamycin (mTOR) inhibition |
| Target: | Serine/threonine-protein kinase mTOR |
| KEGG Pathway: | Choline metabolism in cancer Prostate cancer Insulin signaling pathway mTOR signaling pathway Pathways in cancer Glioma MicroRNAs in cancer Type II diabetes mellitus Adipocytokine signaling pathway Neuroactive ligand-receptor interaction Acute myeloid leukemia AMPK signaling pathway Thyroid hormone signaling pathway PI3K-Akt signaling pathway Central carbon metabolism in cancer HIF-1 signaling pathway |
| Wiki Pathway: | BDNF signaling pathway Polycystic Kidney Disease Pathway Prostate Cancer Senescence and Autophagy in Cancer RANKL/RANK Signaling Pathway Integrated Breast Cancer Pathway MicroRNAs in cardiomyocyte hypertrophy GPCR ligand binding GPCR downstream signaling EGF/EGFR Signaling Pathway Extracellular vesicle-mediated signaling in recipient cells Cardiac Hypertrophic Response Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) FSH signaling pathway SREBF and miR33 in cholesterol and lipid homeostasis Signaling by Insulin receptor GPCRs, Class A Rhodopsin-like PIP3 activates AKT signaling Type II diabetes mellitus AMPK Signaling Leptin signaling pathway Costimulation by the CD28 family TOR Signaling ErbB Signaling Pathway Interferon type I signaling pathways Insulin Signaling Wnt Signaling Pathway Netpath Alpha 6 Beta 4 signaling pathway TSLP Signaling Pathway Peptide GPCRs TSH signaling pathway SREBP signalling Oncostatin M Signaling Pathway |