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| Agent Info | |
| Agent: | sorafenib |
| Synonyms: | Nexavar;Sorafenibum;Sorafenib [INN];Nexavar (TN);Sorafenib (INN);N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea;N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea;N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea;4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide;4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate;4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide;4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide;4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide;4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE |
| Drug Status For Certain Diseases: | Advanced RCC. Unresectable HCC. Locally advanced or metastatic thyroid cancer refractory to radioactive iodine treatment(approved) |
| Classification: | an oral multi-targeted kinase inhibitor targeting kinases that function in tumor cell proliferation and angiogenesis |
| Target: | Vascular endothelial growth factor receptor 1 B-Raf proto-oncogene serine/threonine-protein kinase Proto-oncogene tyrosine-protein kinase receptor ret |
| KEGG Pathway: | Pathways in cancer Rap1 signaling pathway Central carbon metabolism in cancer Endocytosis Transcriptional misregulation in cancer Thyroid cancer Rheumatoid arthritis Ras signaling pathway PI3K-Akt signaling pathway |
| Wiki Pathway: | Signaling Pathways in Glioblastoma Bladder Cancer Focal Adhesion MAPK Signaling Pathway Integrin-mediated Cell Adhesion SIDS Susceptibility Pathways Senescence and Autophagy in Cancer Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell TSH signaling pathway Angiogenesis Serotonin HTR1 Group and FOS Pathway B Cell Receptor Signaling Pathway NGF signalling via TRKA from the plasma membrane Serotonin Receptor 4/6/7 and NR3C Signaling Dopaminergic Neurogenesis EGF/EGFR Signaling Pathway Signaling by VEGF Signaling by FGFR Corticotropin-releasing hormone Polycystic Kidney Disease Pathway Regulation of Actin Cytoskeleton Integrated Breast Cancer Pathway Estrogen signaling pathway MAPK Cascade |