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| Agent Info | |
| Agent: | sunitinib |
| Synonyms: | Sunitanib;Sunitinibum;Sutent;PDGF TK antagonist;SU 11248;SU11248;KS-5022;SU-11248;SU-11248J;SU-12662;Su-011248;Sunitinib (INN);Sunitinib (free base);Sutent (TN);N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;5-(5-FLUORO-2-OXO-1,2-DIHYDRO-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE |
| Drug Status For Certain Diseases: | Advanced RCC, GIST. Unresectable or advanced pancreatic neuroendocrine tumour（approved） |
| Classification: | an oral, multitargeted tyrosine kinase inhibitor of vascular endothelial growth factor receptors and other receptor tyrosine kinases |
| Target: | FL cytokine receptor Mast/stem cell growth factor receptor Vascular endothelial growth factor receptor 2 Platelet-derived growth factor receptor |
| KEGG Pathway: | Central carbon metabolism in cancer Hematopoietic cell lineage Endocytosis Ras signaling pathway Acute myeloid leukemia Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Rap1 signaling pathway Melanogenesis Pathways in cancer VEGF signaling pathway |
| Wiki Pathway: | PIP3 activates AKT signaling Focal Adhesion miR-targeted genes in epithelium - TarBase Signaling by SCF-KIT Differentiation Pathway Cardiac Progenitor Differentiation Nifedipine Activity Angiogenesis miR-targeted genes in muscle cell - TarBase Kit receptor signaling pathway Signaling by VEGF miR-targeted genes in lymphocytes - TarBase |