View Agent
| Agent Info | |
| Agent: | trametinib |
| Synonyms: | GSK1120212 |
| Drug Status For Certain Diseases: | Unresectable or metastatic malignant melanoma with BRAF V600E or V600K mutation(approved) |
| Classification: | an oral, reversible, highly selective allosteric inhibitor of MEK1/2 activation and kinase activity |
| Target: | MEK2 Dual specificity mitogen-activated protein kinase kinase 1 |
| KEGG Pathway: | NA |
| Wiki Pathway: | Oncostatin M Signaling Pathway L1CAM interactions Corticotropin-releasing hormone RANKL/RANK Signaling Pathway Serotonin HTR1 Group and FOS Pathway MAPK Signaling Pathway IL-6 signaling pathway Cardiac Hypertrophic Response MAP kinase activation in TLR cascade Amyotrophic lateral sclerosis (ALS) Estrogen signaling pathway Senescence and Autophagy in Cancer IL-3 Signaling Pathway Aryl Hydrocarbon Receptor AGE/RAGE pathway IL-2 Signaling Pathway EGF/EGFR Signaling Pathway MAPK Cascade Signaling of Hepatocyte Growth Factor Receptor RAF/MAP kinase cascade Nanoparticle-mediated activation of receptor signaling IL-1 signaling pathway Integrin-mediated Cell Adhesion EPO Receptor Signaling B Cell Receptor Signaling Pathway PDGF Pathway Osteopontin Signaling TCR Signaling Pathway BDNF signaling pathway Prostate Cancer IL-9 Signaling Pathway ErbB Signaling Pathway Focal Adhesion Endothelin Pathways Toll-like receptor signaling pathway Serotonin Receptor 2 and ELK-SRF/GATA4 signaling Bladder Cancer TSLP Signaling Pathway Leptin signaling pathway MicroRNAs in cardiomyocyte hypertrophy Regulation of toll-like receptor signaling pathway Nifedipine Activity Integrated Pancreatic Cancer Pathway Regulation of Actin Cytoskeleton Kit receptor signaling pathway Structural Pathway of Interleukin 1 (IL-1) Genes and (Common) Pathways Underlying Drug Addiction Interleukin-11 Signaling Pathway Signaling Pathways in Glioblastoma Serotonin Receptor 4/6/7 and NR3C Signaling TSH signaling pathway Signaling by FGFR IL-7 Signaling Pathway TGF beta Signaling Pathway Insulin Signaling IL-5 Signaling Pathway Hypothetical Network for Drug Addiction |