| ncRNA Symbol: | AGR2 | | Full Name: | anterior gradient 2, protein disulphide isomerase family member | | Category: | mRNA | | Synonyms: | AG-2|AG2|GOB-4|HAG-2|HEL-S-116|HPC8|PDIA17|XAG-2 | | Chromosome: | chr7 | | Strand: | - | | Coordinate: | | Start Site(bp): | 16791811 | End Site(bp): | 16833433 |
| | Gene Summary: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017] | | External Links: | |
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