| ncRNA Symbol: | HLA-E | | Full Name: | major histocompatibility complex, class I, E | | Category: | mRNA | | Synonyms: | HLA-6.2|QA1 | | Chromosome: | chr6 | | Strand: | + | | Coordinate: | | Start Site(bp): | 30489467 | End Site(bp): | 30494205 |
| | Gene Summary: | HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008] | | External Links: | |
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