ctcRbase

Entry Detail

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General Information

Database ID: BRCA00383 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: RPL22 Full Name: ribosomal protein L22 Category: mRNA Synonyms: EAP|HBP15|HBP15/L22|L22 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 6181269 End Site(bp): 6209389 Gene Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000116251 HGNC ID: HGNC:10315 Entrez Gene: 6146

Expression Profile of RPL22 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-210-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-300 YES YES YES hsa-miR-342-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-448 YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-93-5p YES YES NO Display: