| ncRNA Symbol: | HLA-F | | Full Name: | major histocompatibility complex, class I, F | | Category: | mRNA | | Synonyms: | CDA12|HLA-5.4|HLA-CDA12|HLAF | | Chromosome: | chr6 | | Strand: | + | | Coordinate: | | Start Site(bp): | 29722775 | End Site(bp): | 29738528 |
| | Gene Summary: | This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008] | | External Links: | |
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