ctcRbase

Entry Detail

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General Information

Database ID: BRCA00542 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: CALM2 Full Name: calmodulin 2 Category: mRNA Synonyms: CALM|CALML2|CAM1|CAM3|CAMC|CAMII|CAMIII|LQT15|PHKD|PHKD2|caM Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 47160082 End Site(bp): 47176601 Gene Summary: This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] External Links: Ensembl ID: ENSG00000143933 HGNC ID: HGNC:1445 Entrez Gene: 805

Expression Profile of CALM2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-100-5p YES YES NO hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-448 YES YES YES hsa-miR-454-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-613 YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-876-5p YES YES NO hsa-miR-99a-5p YES YES NO hsa-miR-99b-5p YES YES NO Display: