ctcRbase

Entry Detail

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General Information

Database ID: BRCA00568 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PGK1 Full Name: phosphoglycerate kinase 1 Category: mRNA Synonyms: HEL-S-68p|MIG10|PGKA Chromosome: chrX Strand: + Coordinate: Start Site(bp): 78065188 End Site(bp): 78129296 Gene Summary: The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014] External Links: Ensembl ID: ENSG00000102144 HGNC ID: HGNC:8896 Entrez Gene: 5230

Expression Profile of PGK1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-141-3p YES YES NO hsa-miR-143-3p YES NO YES hsa-miR-146a-5p YES YES YES hsa-miR-146b-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-365a-3p YES NO YES hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-425-5p YES NO YES hsa-miR-452-5p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES YES hsa-miR-495-3p YES NO YES hsa-miR-542-3p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-873-5p YES YES YES Display: