ctcRbase

Entry Detail

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General Information

Database ID: BRCA00659 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: RAN Full Name: RAN, member RAS oncogene family Category: mRNA Synonyms: ARA24|Gsp1|TC4 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 130871879 End Site(bp): 130877678 Gene Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000132341 HGNC ID: HGNC:9846 Entrez Gene: 5901

Expression Profile of RAN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-134-5p YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-140-5p YES NO YES hsa-miR-144-3p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-205-5p YES NO YES hsa-miR-206 YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-324-5p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-495-3p YES YES YES hsa-miR-613 YES YES NO hsa-miR-802 YES NO YES Display: