ctcRbase

Entry Detail

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General Information

Database ID: BRCA00748 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: TPT1 Full Name: tumor protein, translationally-controlled 1 Category: mRNA Synonyms: HRF|TCTP|p02|p23 Chromosome: chr13 Strand: - Coordinate: Start Site(bp): 45333471 End Site(bp): 45341370 Gene Summary: This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000133112 HGNC ID: HGNC:12022 Entrez Gene: 7178

Expression Profile of TPT1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-216b-5p NO NO YES hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-371a-5p YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-455-3p YES NO YES hsa-miR-489-3p YES NO YES Display: