ctcRbase

Entry Detail

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General Information

Database ID: BRCA00769 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: SKP1 Full Name: S-phase kinase associated protein 1 Category: mRNA Synonyms: EMC19|OCP-II|OCP2|SKP1A|TCEB1L|p19A Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 134148935 End Site(bp): 134177038 Gene Summary: This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000113558 HGNC ID: HGNC:10899 Entrez Gene: 6500

Expression Profile of SKP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1224-5p YES NO YES hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-145-5p YES YES YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-340-5p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-371a-5p YES YES YES hsa-miR-377-3p YES NO YES hsa-miR-382-5p YES YES YES hsa-miR-433-3p YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-454-3p YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-582-5p YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-7-5p YES YES YES Display: