ctcRbase

Entry Detail

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General Information

Database ID: BRCA00805 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: CLDN11 Full Name: claudin 11 Category: mRNA Synonyms: OSP|OTM Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 170418865 End Site(bp): 170860380 Gene Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010] External Links: Ensembl ID: ENSG00000013297 HGNC ID: HGNC:8514 Entrez Gene: 5010

Expression Profile of CLDN11 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-100-5p YES YES YES hsa-miR-101-3p YES YES YES hsa-miR-137 YES NO YES hsa-miR-153-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-205-5p YES YES YES hsa-miR-25-3p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-328-3p YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-363-3p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-367-3p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES YES hsa-miR-448 YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-499a-5p YES YES YES hsa-miR-501-3p YES NO YES hsa-miR-502-3p YES NO YES hsa-miR-625-5p YES NO NO hsa-miR-873-5p YES NO YES hsa-miR-876-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-99a-5p YES YES YES hsa-miR-99b-5p YES YES YES Display: