| ncRNA Symbol: | PSMA7 |
| Full Name: | proteasome subunit alpha 7 |
| Category: | mRNA |
| Synonyms: | C6|HEL-S-276|HSPC|RC6-1|XAPC7 |
| Chromosome: | chr20 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 62136735 | End Site(bp): | 62143440 |
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| Gene Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012] |
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