ctcRbase

Entry Detail

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General Information

Database ID: BRCA00898 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: CDC42 Full Name: cell division cycle 42 Category: mRNA Synonyms: CDC42Hs|G25K|TKS Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 22052627 End Site(bp): 22092946 Gene Summary: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013] External Links: Ensembl ID: ENSG00000070831 HGNC ID: HGNC:1736 Entrez Gene: 998

Expression Profile of CDC42 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO NO hsa-miR-107 YES NO NO hsa-miR-129-5p YES YES NO hsa-miR-1323 YES NO NO hsa-miR-137 YES YES YES hsa-miR-139-5p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-185-5p YES YES YES hsa-miR-186-5p YES NO YES hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-206 YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-330-3p YES NO YES hsa-miR-342-3p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES NO hsa-miR-448 YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-496 YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES NO NO hsa-miR-543 YES YES NO hsa-miR-548o-3p YES NO NO hsa-miR-613 YES YES YES hsa-miR-655-3p YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: