ctcRbase

Entry Detail

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General Information

Database ID: BRCA00919 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: CFL1 Full Name: cofilin 1 Category: mRNA Synonyms: CFL|HEL-S-15|cofilin Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 65823022 End Site(bp): 65862026 Gene Summary: The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004] External Links: Ensembl ID: ENSG00000172757 HGNC ID: HGNC:1874 Entrez Gene: 1072

Expression Profile of CFL1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-1271-5p YES NO YES hsa-miR-182-5p YES YES YES hsa-miR-370-3p YES NO YES hsa-miR-491-5p YES YES NO hsa-miR-493-3p YES NO YES hsa-miR-543 YES YES YES hsa-miR-96-5p YES NO YES Display: