ctcRbase

Entry Detail

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General Information

Database ID: BRCA00953 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: DUSP1 Full Name: dual specificity phosphatase 1 Category: mRNA Synonyms: CL100|HVH1|MKP-1|MKP1|PTPN10 Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 172768090 End Site(bp): 172771195 Gene Summary: The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000120129 HGNC ID: HGNC:3064 Entrez Gene: 1843

Expression Profile of DUSP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-101-3p YES YES YES hsa-miR-127-3p YES YES NO hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-137 YES NO YES hsa-miR-141-3p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-194-5p YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES NO YES hsa-miR-32-5p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-363-3p YES NO YES hsa-miR-365a-3p YES YES NO hsa-miR-367-3p YES NO YES hsa-miR-370-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-411-5p YES YES YES hsa-miR-429 YES YES YES hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-758-3p YES NO YES hsa-miR-92a-3p YES NO YES hsa-miR-92b-3p YES NO YES hsa-miR-98-5p YES YES YES Display: