ctcRbase

Entry Detail

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General Information

Database ID: BRCA01042 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: LMNA Full Name: lamin A/C Category: mRNA Synonyms: CDCD1|CDDC|CMD1A|CMT2B1|EMD2|FPL|FPLD|FPLD2|HGPS|IDC|LDP1|LFP|LGMD1B|LMN1|LMNC|LMNL1|MADA|PRO1 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 156082573 End Site(bp): 156140089 Gene Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012] External Links: Ensembl ID: ENSG00000160789 HGNC ID: HGNC:6636 Entrez Gene: 4000

Expression Profile of LMNA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-129-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-642a-5p YES NO NO hsa-miR-9-5p YES YES YES hsa-miR-96-5p YES YES NO Display: