ctcRbase

Entry Detail

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General Information

Database ID: BRCA01127 Cancer Type: breast cancer Dataset: GSE86978 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: DYNLL1 Full Name: dynein light chain LC8-type 1 Category: mRNA Synonyms: DLC1|DLC8|DNCL1|DNCLC1|LC8|LC8a|PIN|hdlc1 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 120469850 End Site(bp): 120498493 Gene Summary: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000088986 HGNC ID: HGNC:15476 Entrez Gene: 8655

Expression Profile of DYNLL1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1-3p YES YES NO hsa-miR-204-5p YES NO YES hsa-miR-206 YES YES NO hsa-miR-211-5p YES NO YES hsa-miR-300 YES YES NO hsa-miR-326 YES YES YES hsa-miR-330-5p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-486-5p YES YES YES hsa-miR-613 YES YES NO hsa-miR-874-3p YES YES YES hsa-miR-876-5p YES YES NO Display: