ctcRbase

Entry Detail

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General Information

Database ID: BRCA01146 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: TPM3 Full Name: tropomyosin 3 Category: mRNA Synonyms: CAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 154155304 End Site(bp): 154194648 Gene Summary: This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] External Links: Ensembl ID: ENSG00000143549 HGNC ID: HGNC:12012 Entrez Gene: 7170

Expression Profile of TPM3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-139-5p YES NO YES hsa-miR-1-3p YES YES YES hsa-miR-143-3p YES YES YES hsa-miR-145-5p YES YES YES hsa-miR-150-5p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-195-5p YES YES NO hsa-miR-204-5p YES NO YES hsa-miR-206 YES YES YES hsa-miR-211-5p YES NO YES hsa-miR-214-3p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-218-5p YES NO YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-330-3p YES NO YES hsa-miR-338-3p YES YES YES hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-503-5p YES NO NO hsa-miR-543 YES NO YES hsa-miR-613 YES YES YES hsa-miR-9-5p YES YES YES Display: