ctcRbase

Entry Detail

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General Information

Database ID: BRCA01175 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PTP4A2 Full Name: protein tyrosine phosphatase type IVA, member 2 Category: mRNA Synonyms: HH13|HH7-2|HU-PP-1|OV-1|PRL-2|PRL2|PTP4A|PTPCAAX2|ptp-IV1a|ptp-IV1b Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 31906421 End Site(bp): 31944856 Gene Summary: The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010] External Links: Ensembl ID: ENSG00000184007 HGNC ID: HGNC:9635 Entrez Gene: 8073

Expression Profile of PTP4A2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-375 YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-455-5p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-7-5p YES YES NO hsa-miR-93-5p YES YES NO Display: