Entry Detail



General Information

Database ID:BRCA01214
Cancer Type:breast cancer
Dataset:GSE55807
CTCs/CTM Isolation Method:CTC-iChip



Gene Information

ncRNA Symbol:PSMD8
Full Name:proteasome 26S subunit, non-ATPase 8
Category:mRNA
Synonyms:HEL-S-91n|HIP6|HYPF|Nin1p|Rpn12|S14|p31
Chromosome:chr19
Strand:+
Coordinate:
Start Site(bp):38374536End Site(bp):38383824
Gene Summary:The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
External Links:
Ensembl ID:ENSG00000099341
HGNC ID:HGNC:9566
Entrez Gene:5714



Expression Profile of PSMD8 Gene

 







Regulatory Relationship

mRNA targets:NA
miRNA targets:
miRNA NamePITAmiRandaRNAhybrid
hsa-miR-1-3p
YES
YES
NO
hsa-miR-206
YES
YES
NO
hsa-miR-365a-3p
YES
YES
NO
hsa-miR-485-5p
YES
YES
NO
hsa-miR-613
YES
YES
NO
hsa-miR-653-5p
YES
YES
NO
hsa-miR-874-3p
YES
YES
NO
Display: