ncRNA Symbol: | PSMD8 | Full Name: | proteasome 26S subunit, non-ATPase 8 | Category: | mRNA | Synonyms: | HEL-S-91n|HIP6|HYPF|Nin1p|Rpn12|S14|p31 | Chromosome: | chr19 | Strand: | + | Coordinate: | Start Site(bp): | 38374536 | End Site(bp): | 38383824 | | Gene Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008] | External Links: | |
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