ctcRbase

Entry Detail

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General Information

Database ID: BRCA01218 Cancer Type: breast cancer Dataset: GSE86978 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PKM Full Name: pyruvate kinase M1/2 Category: mRNA Synonyms: CTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1 Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 72199029 End Site(bp): 72231822 Gene Summary: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011] External Links: Ensembl ID: ENSG00000067225 HGNC ID: HGNC:9021 Entrez Gene: 5315

Expression Profile of PKM Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES YES YES hsa-miR-148a-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-625-5p YES NO NO Display: