ctcRbase

Entry Detail

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General Information

Database ID: BRCA01279 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MLPH Full Name: melanophilin Category: mRNA Synonyms: SLAC2-A Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 237485428 End Site(bp): 237555318 Gene Summary: This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] External Links: Ensembl ID: ENSG00000115648 HGNC ID: HGNC:29643 Entrez Gene: 79083

Expression Profile of MLPH Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-134-5p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-488-3p YES YES NO Display: