ctcRbase

Entry Detail

General Information

Database ID:	BRCA01305
Cancer Type:	breast cancer
Dataset:	GSE111065
CTCs/CTM Isolation Method:	microfluidics immunofluorescence

Gene Information

ncRNA Symbol:

HLA-C

Full Name:

major histocompatibility complex, class I, C

Category:

mRNA

Synonyms:

Chromosome:

chr6

Strand:

Coordinate:

Start Site(bp):

31268749

End Site(bp):

31272130

Gene Summary:

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

External Links:

Ensembl ID:	ENSG00000204525
HGNC ID:	HGNC:4933
Entrez Gene:	3107

Expression Profile of HLA-C Gene

Regulatory Relationship

mRNA targets:

miRNA targets:

miRNA Name	PITA	miRanda	RNAhybrid
hsa-miR-146a-5p	YES	YES	NO
hsa-miR-146b-5p	YES	YES	NO
hsa-miR-148a-3p	YES	YES	NO
hsa-miR-148b-3p	YES	YES	NO
hsa-miR-152-3p	YES	YES	NO
hsa-miR-181a-5p	YES	YES	NO
hsa-miR-181b-5p	YES	YES	NO
hsa-miR-181c-5p	YES	YES	NO
hsa-miR-181d-5p	YES	YES	NO
hsa-miR-224-5p	YES	YES	NO
hsa-miR-23a-3p	YES	YES	NO
hsa-miR-23b-3p	YES	YES	NO
hsa-miR-376a-3p	YES	YES	NO
hsa-miR-376b-3p	YES	YES	NO
hsa-miR-491-5p	YES	YES	NO
hsa-miR-873-5p	YES	YES	NO

Display: