ctcRbase

Entry Detail

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General Information

Database ID: BRCA01365 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: ITM2B Full Name: integral membrane protein 2B Category: mRNA Synonyms: ABRI|BRI|BRI2|BRICD2B|E25B|E3-16|FBD|RDGCA|imBRI2 Chromosome: chr13 Strand: + Coordinate: Start Site(bp): 48233158 End Site(bp): 48270357 Gene Summary: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009] External Links: Ensembl ID: ENSG00000136156 HGNC ID: HGNC:6174 Entrez Gene: 9445

Expression Profile of ITM2B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-143-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-224-5p YES YES YES hsa-miR-25-3p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-339-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-384 YES YES NO hsa-miR-429 YES YES YES hsa-miR-448 YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-542-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-9-5p YES YES YES Display: