ctcRbase

Entry Detail

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General Information

Database ID: BRCA01412 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: LITAF Full Name: lipopolysaccharide induced TNF factor Category: mRNA Synonyms: PIG7|SIMPLE|TP53I7 Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 11547722 End Site(bp): 11636381 Gene Summary: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014] External Links: Ensembl ID: ENSG00000189067 HGNC ID: HGNC:16841 Entrez Gene: 9516

Expression Profile of LITAF Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-124-3p YES NO YES hsa-miR-1-3p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-182-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-206 YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-21-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-450a-5p YES YES YES hsa-miR-497-5p YES YES YES hsa-miR-506-3p YES NO YES hsa-miR-519d-3p YES YES YES hsa-miR-590-5p YES YES NO hsa-miR-613 YES YES NO hsa-miR-93-5p YES YES YES Display: