ctcRbase

Entry Detail

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General Information

Database ID: BRCA01578 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: APP Full Name: amyloid beta precursor protein Category: mRNA Synonyms: AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 Chromosome: chr21 Strand: - Coordinate: Start Site(bp): 25880550 End Site(bp): 26171128 Gene Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] External Links: Ensembl ID: ENSG00000142192 HGNC ID: HGNC:620 Entrez Gene: 351

Expression Profile of APP Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-1297 YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-149-5p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-185-5p YES YES YES hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-300 YES YES YES hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-323a-3p YES NO YES hsa-miR-324-5p YES YES YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-381-3p YES YES YES hsa-miR-383-5p YES YES YES hsa-miR-384 YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-532-3p YES NO YES hsa-miR-582-5p YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-873-5p YES YES YES hsa-miR-93-5p YES YES YES Display: