ctcRbase

Entry Detail

---



General Information

Database ID: BRCA04182 Cancer Type: breast cancer Dataset: GSE86978 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: EIF4G2 Full Name: eukaryotic translation initiation factor 4 gamma 2 Category: mRNA Synonyms: AAG1|DAP5|NAT1|P97 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 10797050 End Site(bp): 10809110 Gene Summary: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000110321 HGNC ID: HGNC:3297 Entrez Gene: 1982

Expression Profile of EIF4G2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-101-3p YES YES YES hsa-miR-103a-3p YES YES NO hsa-miR-106a-5p YES NO YES hsa-miR-106b-5p YES YES YES hsa-miR-107 YES YES NO hsa-miR-1297 YES YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-137 YES YES YES hsa-miR-139-5p YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-140-5p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-146a-5p YES YES YES hsa-miR-146b-5p YES YES YES hsa-miR-17-5p YES NO YES hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-194-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-208a-3p YES YES YES hsa-miR-208b-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES NO YES hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-300 YES YES YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-379-5p YES YES YES hsa-miR-381-3p YES YES YES hsa-miR-383-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-411-5p YES YES YES hsa-miR-429 YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-499a-5p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-543 YES YES NO hsa-miR-582-5p YES NO YES hsa-miR-613 YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES YES hsa-miR-98-5p YES YES YES Display: