| ncRNA Symbol: | AGR3 | | Full Name: | anterior gradient 3, protein disulphide isomerase family member | | Category: | mRNA | | Synonyms: | AG-3|AG3|BCMP11|HAG3|PDIA18|hAG-3 | | Chromosome: | chr7 | | Strand: | - | | Coordinate: | | Start Site(bp): | 16859405 | End Site(bp): | 16881987 |
| | Gene Summary: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016] | | External Links: | |
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