ctcRbase

Entry Detail

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General Information

Database ID: BRCA04770 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: DR1 Full Name: down-regulator of transcription 1 Category: mRNA Synonyms: NC2|NC2-BETA|NC2B|NCB2 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 93345888 End Site(bp): 93369498 Gene Summary: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000117505 HGNC ID: HGNC:3017 Entrez Gene: 1810

Expression Profile of DR1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-122-5p YES YES YES hsa-miR-132-3p YES YES NO hsa-miR-137 YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-194-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-204-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-224-5p YES YES YES hsa-miR-300 YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-320a YES NO YES hsa-miR-320b YES NO YES hsa-miR-320c YES NO YES hsa-miR-320d YES NO YES hsa-miR-323a-3p YES NO YES hsa-miR-340-5p YES YES YES hsa-miR-361-5p YES YES YES hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES YES hsa-miR-384 YES YES YES hsa-miR-429 YES NO YES hsa-miR-431-5p YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-490-3p YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-496 YES YES NO hsa-miR-543 YES YES YES hsa-miR-582-5p YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-9-5p YES YES YES Display: