ctcRbase

Entry Detail

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General Information

Database ID: BRCA07983 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: CYTH1 Full Name: cytohesin 1 Category: mRNA Synonyms: B2-1|CYTOHESIN-1|D17S811E|PSCD1|SEC7 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 78674048 End Site(bp): 78782297 Gene Summary: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] External Links: Ensembl ID: ENSG00000108669 HGNC ID: HGNC:9501 Entrez Gene: 9267

Expression Profile of CYTH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES YES hsa-miR-10b-5p YES YES YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-129-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-339-5p YES YES YES hsa-miR-369-3p YES NO NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-429 YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-505-3p YES YES YES hsa-miR-5688 NO NO YES Display: